Description
| Product Name: | Nanodisc Human FZD8 Protein |
| SKU: | HDFP238 |
| Size: | 10μg |
| Target: | FZD8 |
| Tag: | C-Flag Tag |
| Expression Host: | HEK293 |
| Conjugate: | Unconjugated |
| Synonyms: | FZ-8, hFZ8 |
| Protein Families: | Transmembrane, Druggable Genome. |
| Protein Description: | Human FZD8 full length protein-synthetic nanodisc |
| Protein Pathways: | Wnt NetPath 8, Wnt signaling, Wnt signaling and pluripotency, Cancer, Notch, Wnt Pathway, Stem Cell. |
| Molecular Weight: | The human full length FZD8 protein has a MW of 73.3kDa |
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
| Uniprot ID: | Q9H461 |
| Formulation & Reconstitution: | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping: | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Usage: | Research use only |
