Description
| Product Name: | Human IRGM Recombinant Protein |
| Product Code: | RPPB3755 |
| Size: | 20µg |
| Species: | Human |
| Target: | IRGM |
| Synonyms: | Immunity-related GTPase family M protein, Immunity-related GTPase family M protein1, LPS-stimulated RAW 264.7 macrophage protein 47 homolog, LRG-47, IRGM, IFI1, IRGM1, LRG47. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The IRGM solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MKETLKIVSR TPVNITMAGD SGNGMSTFIS ALRNTGHEGK ASPPTELVKA TQRCASYFSS HFSNVVLWDL PGTGSATTTL ENYLMEMQFN RYDFIMVASA QFSMNHVMLA KTAEDMGKKF YIVWTKLDMD LSTGALPEVQ LLQIRENVLE NLQKERVCEY |
Immunity-related GTPase family M protein (IRGM) is essential for clearance of severe protozoan and bacterial infections. IRGM belongs to the p47 immunity-related GTPase family. IRGM serves in innate immune response possibly via regulation of autophagy. IRGM regulates proinflammatory cytokine production and inhibit endotoxemia upon infection and also has a part in macrophages adhesion and motility. Polymorphisms which modify the natural expression of the IRGM gene are associated with a susceptibility to Crohn's disease and tuberculosis.
IRGM Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 180 amino acids (23-181) and having a molecular mass of 20.1 kDa. IRGM is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IRGM: Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility. Defects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19). A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Belongs to the interferon-inducible GTPase family. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; EC 3.6.5.-; Hydrolase Chromosomal Location of Human Ortholog: 5q33.1 Disease: Inflammatory Bowel Disease 19; Mycobacterium Tuberculosis, Susceptibility To |
| NCBI Summary: | This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010] |
| UniProt Code: | A1A4Y4 |
| NCBI GenInfo Identifier: | 171473037 |
| NCBI Gene ID: | 345611 |
| NCBI Accession: | A1A4Y4.2 |
| UniProt Secondary Accession: | A1A4Y4,B3VEX0, |
| UniProt Related Accession: | A1A4Y4 |
| Molecular Weight: | 20,142 Da |
| NCBI Full Name: | Immunity-related GTPase family M protein |
| NCBI Synonym Full Names: | immunity related GTPase M |
| NCBI Official Symbol: | IRGM�� |
| NCBI Official Synonym Symbols: | IFI1; IRGM1; LRG47; LRG-47�� |
| NCBI Protein Information: | immunity-related GTPase family M protein |
| UniProt Protein Name: | Immunity-related GTPase family M protein |
| UniProt Synonym Protein Names: | Immunity-related GTPase family M protein 1; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog; LRG-47 |
| Protein Family: | Immunity-related GTPase family M protein |
| UniProt Gene Name: | IRGM�� |
| UniProt Entry Name: | IRGM_HUMAN |
