Description
| Product Name: | Human NBL1 Recombinant Protein |
| Product Code: | RPPB4059 |
| Size: | 20µg |
| Species: | Human |
| Target: | NBL1 |
| Synonyms: | D1S1733E, DAN, DAND1, NB, NO3, Neuroblastoma suppressor of tumorigenicity 1, DAN domain family member 1, Zinc finger protein DAN, NBL1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | NBL1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSAPPPINK LALFPDKSAW CEAKNITQIV GHSGCEAKSI QNRACLGQCF SYSVPNTFPQ STESLVHCDS CMPAQSMWEI VTLECPGHEE VPRVDKLVEK ILHCSCQACG KEPSHEGLSV YVQGEDGPGS QPGTHPHPHP HPHPGGQTPE PEDPPGAPHT EEEGAED |
Neuroblastoma suppressor of tumorigenicity 1 (NBL1) is a part of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in several signaling molecules. NBL1 is a is a tumor suppressor of neuroblastoma and takes part in preventing cells from entering the final stage (G1/S) of the transformation process. NBL1 is produced in small neurons of the dorsal root ganglion. The expression of NBL1 is triggered by MATH-1.
NBL1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 187 amino acids (18-181 a.a) and having a molecular mass of 20kDa. NBL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | NBL1 iso2: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Belongs to the DAN family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Tumor suppressor; Secreted Chromosomal Location of Human Ortholog: 1p36.13 Cellular Component: extracellular space Molecular Function:morphogen activity; protein homodimerization activity Biological Process: nervous system development; determination of dorsal identity; positive regulation of neuron differentiation; neurite morphogenesis; negative regulation of BMP signaling pathway |
| NCBI Summary: | This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013] |
| UniProt Code: | P41271 |
| NCBI GenInfo Identifier: | 323276675 |
| NCBI Gene ID: | 4681 |
| NCBI Accession: | NP_001191013.1 |
| UniProt Secondary Accession: | P41271,Q5TGZ2, Q5U0N4, Q96L68, A3KFI7, |
| UniProt Related Accession: | P41271 |
| Molecular Weight: | 19,277 Da |
| NCBI Full Name: | neuroblastoma suppressor of tumorigenicity 1 isoform 2 |
| NCBI Synonym Full Names: | neuroblastoma 1, DAN family BMP antagonist |
| NCBI Official Symbol: | NBL1�� |
| NCBI Official Synonym Symbols: | NB; DAN; NO3; DAND1; D1S1733E�� |
| NCBI Protein Information: | neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; neuroblastoma candidate region, suppression of tumorigenicity 1 |
| UniProt Protein Name: | Neuroblastoma suppressor of tumorigenicity 1 |
| UniProt Synonym Protein Names: | DAN domain family member 1; Protein N03; Zinc finger protein DAN |
| Protein Family: | D-aminoacylase |
| UniProt Gene Name: | NBL1�� |
| UniProt Entry Name: | NBL1_HUMAN |
