The IGF1R Polyclonal Antibody (CAB14698) is specifically engineered for research involving the insulin-like growth factor 1 receptor (IGF1R), a key cell surface receptor implicated in growth and development processes. This antibody, produced through rabbit immunization, exhibits high reactivity towards human IGF1R samples and has been validated for use in Western blotting applications. By targeting the IGF1R protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for investigations in molecular biology and cancer research.IGF1R plays a crucial role in the regulation of cell growth, differentiation, and survival, making it a promising target for studies related to cancer biology, endocrinology, and developmental biology.
Understanding the functions and signaling pathways of IGF1R is essential for unraveling its involvement in diseases such as cancer, diabetes, and growth disorders. This antibody provides researchers with a reliable tool for investigating the complex mechanisms underlying IGF1R activation and its impact on cellular processes, paving the way for potential therapeutic interventions in diverse medical conditions.
Product Name:
IGF1R Rabbit Polyclonal Antibody
SKU:
CAB14698
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 741-910 of human IGF1R (NP_000866.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
155kDa
Observed MW:
110kDa
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3480
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IGF1R Rabbit pAb (CAB14698) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
