The IKZF4 (IKAROS Family Zinc Finger 4) Polyclonal Antibody (PAC020958) is a valuable tool for researchers studying the role of IKZF4 in immune regulation and cell differentiation. This antibody, raised in rabbits, is highly specific to IKZF4 and has been validated for use in Western blot and immunohistochemistry applications.IKZF4 is a transcription factor that plays a critical role in the development and function of immune cells, particularly T cells and B cells. It is involved in the regulation of gene expression and the differentiation of these cells into their specialized subsets. Dysregulation of IKZF4 expression has been linked to various autoimmune diseases, leukemia, and lymphoma, making it a key target for therapeutic interventions.
By using the IKZF4 Polyclonal Antibody, researchers can accurately detect and analyze IKZF4 protein levels in various cell types and tissues, providing valuable insights into the molecular mechanisms underlying immune responses and disease pathology. This antibody is a valuable tool for those interested in advancing our understanding of immune cell development and function, as well as for those seeking to identify novel therapeutic targets for immune-related disorders.
Antibody Name:
IKZF4 Antibody (PACO20958)
Antibody SKU:
PACO20958
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:20-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human IKZF4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO20958(IKZF4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20958(IKZF4 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.
Synonyms:
IKAROS family zinc finger 4 (Eos)
UniProt Protein Function:
IKZF4: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Belongs to the Ikaros C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:C2H2-type zinc finger protein; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: nucleus
Molecular Function:protein homodimerization activity; sequence-specific DNA binding; protein heterodimerization activity; metal ion binding; bHLH transcription factor binding; transcription factor activity
Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
NCBI Summary:
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
