The IKZF4 Polyclonal Antibody (PAC020959) is a valuable tool for researchers studying IKZF4, a key transcription factor involved in immune cell development and function. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for Western blot applications. By targeting the IKZF4 protein, this antibody enables the detection and analysis of IKZF4 expression in various cell types, providing insights into its role in immune regulation and disease development.IKZF4, also known as Eos, plays a crucial role in the differentiation and function of T cells, B cells, and other immune cells.
Dysregulation of IKZF4 has been linked to autoimmune diseases, leukemia, and other immune-related disorders, highlighting its importance in immune system integrity. Research on IKZF4 can offer valuable insights into disease mechanisms and potential therapeutic targets for immune-related conditions.Overall, the IKZF4 Polyclonal Antibody is a valuable tool for investigating the role of IKZF4 in immune function and disease, and it is a valuable asset for researchers working in immunology, cancer biology, and autoimmune disease research.
Antibody Name:
IKZF4 Antibody (PACO20959)
Antibody SKU:
PACO20959
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human IKZF4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20959(IKZF4 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.
Synonyms:
IKAROS family zinc finger 4 (Eos)
UniProt Protein Function:
IKZF4: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Belongs to the Ikaros C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:C2H2-type zinc finger protein; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: nucleus
Molecular Function:protein homodimerization activity; sequence-specific DNA binding; protein heterodimerization activity; metal ion binding; bHLH transcription factor binding; transcription factor activity
Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
NCBI Summary:
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
