Description
IL12B Antibody (PACO27589)
The IL12B Monoclonal Antibody (PACO27589) is a valuable tool for researchers studying IL12B, a cytokine involved in immune responses and inflammatory processes. This antibody, generated in mice, demonstrates high specificity for human IL12B and is validated for use in various applications including Western blot and ELISA.IL12B, also known as interleukin-12 subunit beta, plays a crucial role in activating natural killer cells and promoting the differentiation of T cells into Th1 cells.
Its involvement in regulating immune responses makes it a key target for research in autoimmune diseases, infectious diseases, and cancer. The IL12B Monoclonal Antibody enables precise detection and analysis of IL12B expression in different cell types, providing valuable insights into its function and potential therapeutic applications.
| Antibody Name: | IL12B Antibody (PACO27589) |
| Antibody SKU: | PACO27589 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| Species Reactivity: | Sheep |
| Immunogen: | Recombinant Sheep Interleukin-12 subunit β protein (23-327AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Interleukin-12 subunit beta antibody at 14µg/ml + K562 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 37 kDa Observed band size: 37 kDa . |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO27589 at dilution of 1:10. |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO27589 at dilution of 1:10. |
| Background: | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-γ by resting PBMC By similarity.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis By similarity. |
| Synonyms: | Interleukin-12 subunit β (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40), IL12B |
| UniProt Protein Function: | |
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| NCBI Summary: | |
| UniProt Code: | P68220 |
| NCBI GenInfo Identifier: | 57164231 |
| NCBI Gene ID: | 443472 |
| NCBI Accession: | NP_001009438.1 |
| UniProt Secondary Accession: | P68220 |
| UniProt Related Accession: | P68220 |
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| NCBI Full Name: | interleukin-12 subunit beta |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | IL12BÂ Â |
| NCBI Official Synonym Symbols: | IL-12Â Â |
| NCBI Protein Information: | interleukin-12 subunit beta |
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