The IL17RC Monoclonal Antibody (PACO06582) is a valuable tool for researchers studying the IL17RC protein, a key player in inflammation and immune response regulation. This antibody, produced in mice, exhibits high specificity and sensitivity to IL17RC in human samples and is validated for use in various applications, including Western blot and immunohistochemistry.IL17RC, also known as the interleukin-17 receptor C, is a crucial receptor in the IL-17 cytokine family, involved in mediating inflammatory responses and immune cell activation. Research has shown that dysregulation of IL17RC signaling is associated with various inflammatory diseases, making it an important target for therapeutic intervention.
By utilizing the IL17RC Monoclonal Antibody, researchers can accurately detect and analyze IL17RC expression in different cell types and tissue samples, providing insights into its role in health and disease. This antibody is a valuable tool for studies in immunology, inflammation, and autoimmune disorders, contributing to the advancement of biomedical research and the development of novel therapeutic strategies.
Antibody Name:
IL17RC Antibody (PACO06582)
Antibody SKU:
PACO06582
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the C-terminal region of human IL-17RC.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of LOVO cells using IL-17RC Polyclonal Antibody.
Western Blot analysis of HuvEc cells using IL-17RC Polyclonal Antibody.
IL17RC: a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 3p25.3|3p25.3-p24.1Cellular Component: integral to plasma membraneMolecular Function: interleukin-17 receptor activityBiological Process: cytokine and chemokine mediated signaling pathwayDisease: Candidiasis, Familial, 9
UniProt Protein Details:
NCBI Summary:
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
