The INHBB Polyclonal Antibody (PACO18105) is a valuable tool for researchers studying INHBB, a protein involved in various biological processes, including cell growth, differentiation, and development. This antibody, generated in rabbits, has high specificity for human samples and has been validated for use in Western blotting applications. It binds specifically to the INHBB protein, allowing for precise detection and analysis in a variety of cell types.INHBB, also known as Inhibin Beta B, is particularly important in the regulation of reproductive processes, such as follicle-stimulating hormone secretion and ovarian steroidogenesis.
Additionally, it has been implicated in cancer progression and metastasis, making it a promising target for cancer research. By understanding the function of INHBB, researchers can gain valuable insights into its role in both normal physiological processes and disease states, ultimately leading to the development of novel therapeutic strategies.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18105(INHBB Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse kidney tissue, Primary antibody: PACO18105(INHBB Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18105(INHBB Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The inhibin β B subunit joins the α subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.
Synonyms:
inhibin, β B
UniProt Protein Function:
INHBB: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.
UniProt Protein Details:
Protein type:Secreted, signal peptide; Cytokine; Secreted; Cell development/differentiation
Chromosomal Location of Human Ortholog: 2cen-q13
Cellular Component: extracellular region; extracellular space; perinuclear region of cytoplasm
Biological Process: activin receptor signaling pathway; cell development; cell differentiation; cellular response to insulin stimulus; cellular response to starvation; defense response; fat cell differentiation; growth; negative regulation of follicle-stimulating hormone secretion; negative regulation of hepatocyte growth factor biosynthetic process; negative regulation of insulin secretion; oocyte development; ovarian follicle development; positive regulation of follicle-stimulating hormone secretion; regulation of apoptosis; regulation of MAPKKK cascade; response to mechanical stimulus
NCBI Summary:
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]
