Description
IL17A Antibody (CAB0688)
The IL17A Antibody (CAB0688) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, has high specificity for human samples and is suitable for use in Western blot applications. By binding to IL-17A, it allows for accurate detection and analysis in various cell types, making it ideal for investigations in immunology and inflammatory disease research.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
| Product Name: | IL17A Antibody |
| SKU: | CAB0688 |
| Size: | 20μL, 100μL |
| Reactivity: | Human |
| Conjugate: | Unconjugated |
| Immunogen: | Recombinant protein (or fragment).This information is considered to be commercially sensitive. | ||||||
| Sequence: | GITI PRNP GCPN SEDK NFPR TVMV NLNI HNRN TNTN PKRS SDYY NRST SPWN LHRN EDPE RYPS VIWE AKCR HLGC INAD GNVD YHMN SVPI QQEI LVLR REPP HCPN SFRL EKIL VSVG CTCV TPIV HHVA | ||||||
| Tested Applications: | WB ELISA | ||||||
| Recommended Dilution: |
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| Synonyms: | IL17, CTLA8, IL-17, ILA17, CTLA-8, IL-17A, IL17A |
| Positive Sample: | Recombinant Human IL-17A Protein |
| Cellular Localization: | Secreted. |
| Calculated MW: | 18kDa |
| Observed MW: | 18-25kDa |
This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A.
| Purification Method | Affinity purification |
| Gene ID | 3605 |
| RRID | AB_2757339 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of various lysates, using IL17A Rabbit pAb (CAB0688) at 1:500 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30s. |
