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IP3R Polyclonal Antibody (CAB21471)

SKU:
CAB21471
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
IP
€129 - €359
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:IP3R Polyclonal Antibody
SKU:CAB21471
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1812-1911 of human IP3R (NP_001365381).
Sequence:ASNL VIDL IMNA SSDR VFHE SILL AIAL LEGG NTTI QHSF FCRL TEDK KSEK FFKV FYDR MKVA QQEI KATV TVNT SDLG NKKK DDEV DRDA PSRK KAKE
Tested Applications:WB IF/ICC IP ELISA
Recommended Dilution:WB,1:1000 - 1:5000 IF/ICC,1:50 - 1:200 IP,0.5ug-4ug antibody for 200ug-400ug extracts of whole cells
Synonyms:ACV; CLA4; IP3R; IP3R1; SCA15; SCA16; SCA29; INSP3R1; PPP1R94
Positive Sample:U-87 MG,SH-SY5Y
Conjugate:Unconjugated
Cellular Localization:Endoplasmic reticulum membrane, Multi-pass membrane protein.
Calculated MW:314kDa
Observed MW:320kDa

This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene.

Purification Method:Affinity purification
Gene ID:3708
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using IP3R Rabbit pAb (CAB21471) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC): A-431.Exposure time: 10s.

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