The ISL2 Polyclonal Antibody (PAC021925) is a versatile tool for researchers studying ISL2, a critical transcription factor involved in the development of the nervous system and neurogenesis. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including immunohistochemistry and flow cytometry. It binds to the ISL2 protein, allowing for the detection and analysis of ISL2 expression in different cell types, making it a valuable resource for neuroscience and developmental biology research.
ISL2 plays a crucial role in the differentiation and maturation of neurons, as well as in the regulation of gene expression during neurodevelopment. Understanding the functions of ISL2 is essential for unraveling the mechanisms underlying neural development and function, making this antibody an indispensable tool for investigating neurological diseases and disorders. By targeting ISL2, researchers can gain insights into potential therapeutic strategies for conditions such as neurodegenerative diseases and developmental disorders.
Antibody Name:
ISL2 Antibody (PACO21925)
Antibody SKU:
PACO21925
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from internal of human ISL2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from 293 cells, using ISL2 antibody.
Synonyms:
Insulin gene enhancer protein ISL-2; Islet-2; ISL2;
UniProt Protein Function:
islet-2: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
UniProt Protein Details:
Protein type:DNA-binding
Chromosomal Location of Human Ortholog: 15q23
Cellular Component: nucleus
Molecular Function:DNA binding; sequence-specific DNA binding; zinc ion binding
Biological Process: negative regulation of neuron differentiation; neuron development; peripheral nervous system neuron development; regulation of transcription, DNA-dependent; retinal ganglion cell axon guidance; spinal cord motor neuron cell fate specification; visceral motor neuron differentiation
