The KCNE1 Antibody (CAB1176) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.KCNE1 plays a crucial role in modulating potassium ion channels in the heart, impacting the cardiac action potential and electrical conduction. Dysregulation of KCNE1 has been linked to various cardiac arrhythmias and other cardiovascular conditions. By targeting the KCNE1 protein, researchers can gain insights into the mechanisms underlying these pathologies and potentially develop new therapeutic strategies.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
KCNE1 Antibody
SKU:
CAB1176
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
ISK, JLNS, LQT5, MinK, JLNS2, LQT2/5, KCNE1
Positive Sample:
H460, 293T, U937, Mouse brain
Cellular Localization:
Cell Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:
15kDa
Observed MW:
16kDa
The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.
Purification Method
Affinity purification
Gene ID
3753
RRID
AB_2758741
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using KCNE1 Rabbit pAb (CAB1176) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
