The KCNK17 Polyclonal Antibody (PAC016578) is a valuable tool for researchers studying potassium channels and their role in cellular function. This antibody, produced in rabbits, specifically targets the KCNK17 protein and is highly reactive with human samples. Validated for use in Western blot applications, it allows for the detection and analysis of KCNK17 in various cell types.KCNK17, part of the two-pore domain potassium channel family, plays a crucial role in regulating membrane potential and cell excitability. Understanding the function of KCNK17 is important for research in neuroscience, cardiovascular biology, and epithelial cell physiology.
This antibody enables researchers to investigate the expression and localization of KCNK17, providing insights into its involvement in various physiological processes.The KCNK17 Polyclonal Antibody is a valuable tool for studying potassium channel biology and its impact on cellular physiology. Its high reactivity and specificity make it an ideal choice for researchers interested in unraveling the role of KCNK17 in health and disease.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16578(KCNK17 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: LO2 cells, Primary antibody: PACO16578(KCNK17 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16578(KCNK17 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms:
potassium channel, subfamily K, member 17
UniProt Protein Function:
KCNK17: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6p21.2Cellular Component: integral component of plasma membrane; plasma membraneMolecular Function: potassium channel activity; potassium ion leak channel activity; voltage-gated ion channel activityBiological Process: potassium ion transport; stabilization of membrane potential
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
