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KCNMB3 Antibody (PACO63995)

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SKU:
PACO63995
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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KCNMB3 Antibody (PACO63995)

The KCNMB3 Polyclonal Antibody (PAC063995) is a valuable tool for researchers investigating the KCNMB3 protein, a crucial component in ion channel regulation and calcium signaling. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By binding to the KCNMB3 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential reagent for studies in neuroscience and cardiovascular research.

KCNMB3, also known as the calcium-activated potassium channel subunit beta-3, plays a pivotal role in regulating neuronal excitability and vascular smooth muscle tone. Its involvement in calcium-dependent signaling pathways make it a prime target for investigations into neurological disorders, cardiovascular diseases, and smooth muscle dysfunction. Understanding the function of KCNMB3 is crucial for developing therapies that target ion channel activity and calcium signaling in these pathologies.

Antibody Name:KCNMB3 Antibody (PACO63995)
Antibody SKU:PACO63995
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Calcium-activated potassium channel subunit beta-3 protein (82-207AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Antigen Affinity purified & Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunofluorescence staining of U251 cells with PACO63995 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
Synonyms:Calcium-activated potassium channel subunit beta-3 (BK channel subunit beta-3) (BKbeta3) (Hbeta3) (Calcium-activated potassium channel, subfamily M subunit beta-3) (Charybdotoxin receptor subunit beta-3) (K(VCA)beta-3) (Maxi K channel subunit beta-3) (Slo-beta-3), KCNMB3, KCNMB2 KCNMBL
UniProt Protein Function:KCNMB3: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 3q26.3-q27Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membraneMolecular Function: calcium-activated potassium channel activity; potassium channel regulator activityBiological Process: regulation of action potential; synaptic transmission; generation of action potential; detection of calcium ion; blood coagulation; potassium ion transport
UniProt Protein Details:
NCBI Summary:MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]
UniProt Code:Q9NPA1
NCBI GenInfo Identifier:90111824
NCBI Gene ID:27094
NCBI Accession:Q9NPA1.2
UniProt Secondary Accession:Q9NPA1,Q9NPG7, Q9NRM9, Q9UHN3, B7Z9C9, D3DNR2, E9PER5
UniProt Related Accession:Q9NPA1
Molecular Weight:19,474 Da
NCBI Full Name:Calcium-activated potassium channel subunit beta-3
NCBI Synonym Full Names:potassium large conductance calcium-activated channel, subfamily M beta member 3
NCBI Official Symbol:KCNMB3  
NCBI Official Synonym Symbols:HBETA3; KCNMB2; KCNMBL; BKBETA3; SLOBETA3; SLO-BETA-3; K(VCA)BETA-3  
NCBI Protein Information:calcium-activated potassium channel subunit beta-3; BK channel subunit beta-3; maxi K channel subunit beta-3; charybdotoxin receptor subunit beta-3; calcium-activated potassium channel regulatory subunit; calcium-activated potassium channel, subfamily M subunit beta-3; large conductance, voltage and Ca2+ activated potassium channel Maxi K beta 3 subunit
UniProt Protein Name:Calcium-activated potassium channel subunit beta-3
UniProt Synonym Protein Names:BK channel subunit beta-3; BKbeta3; Hbeta3; Calcium-activated potassium channel, subfamily M subunit beta-3; Charybdotoxin receptor subunit beta-3; K(VCA)beta-3; Maxi K channel subunit beta-3; Slo-beta-3
Protein Family:Calcium-activated potassium channel
UniProt Gene Name:KCNMB3  
UniProt Entry Name:KCMB3_HUMAN
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