KCNT1 Antibody (PACO04828)
- SKU:
- PACO04828
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KCNT1 Antibody (PACO04828)
The KCNT1 Antibody (PAC04828) is a valuable tool for researchers studying the KCNT1 gene, which encodes a sodium-activated potassium channel. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By binding specifically to the KCNT1 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for immunology and neuroscience research.
KCNT1, also known as Slo2.1, plays a crucial role in regulating neuronal excitability and synaptic transmission. Mutations in the KCNT1 gene have been linked to epilepsy and other neurological disorders, making it a promising target for drug development and therapeutic interventions. Understanding the function and regulation of KCNT1 is essential for advancing our knowledge of brain function and developing new treatments for neurological conditions.
| Antibody Name: | KCNT1 Antibody |
| Antibody SKU: | PACO04828 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the C-terminal region of human KCNT1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | KCNT1; KIAA1422; Potassium channel subfamily T member 1; KCa4.1 |
| UniProt Protein Function: | KCNT1: Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro). Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 9q34.3Cellular Component: voltage-gated potassium channel complexMolecular Function: calcium-activated potassium channel activity; voltage-gated potassium channel activityDisease: Epilepsy, Nocturnal Frontal Lobe, 5; Epileptic Encephalopathy, Early Infantile, 14 |
| UniProt Protein Details: | |
| NCBI Summary: | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q5JUK3 |
| NCBI GenInfo Identifier: | 432134244 |
| NCBI Gene ID: | 57582 |
| NCBI Accession: | NP_001258932.1 |
| UniProt Secondary Accession: | Q5JUK3,Q9P2C5, B3KXF7, B7ZVY4, B9EGP2, G5E9V0 |
| UniProt Related Accession: | Q5JUK3 |
| Molecular Weight: | 136,987 Da |
| NCBI Full Name: | potassium channel subfamily T member 1 isoform 2 |
| NCBI Synonym Full Names: | potassium sodium-activated channel subfamily T member 1 |
| NCBI Official Symbol: | KCNT1 |
| NCBI Official Synonym Symbols: | ENFL5; SLACK; EIEE14; KCa4.1; Slo2.2; bA100C15.2 |
| NCBI Protein Information: | potassium channel subfamily T member 1 |
| UniProt Protein Name: | Potassium channel subfamily T member 1 |
| UniProt Synonym Protein Names: | KCa4.1 |
| Protein Family: | Potassium channel subfamily |
| UniProt Gene Name: | KCNT1 |
| UniProt Entry Name: |
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