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KCNT1 Antibody (PACO57176)

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SKU:
PACO57176
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • KCNT1 Antibody PACO57176
  • KCNT1 Antibody PACO57176
€339

Description

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KCNT1 Antibody (PACO57176)

The KCNT1 Polyclonal Antibody (PACO57176) is a valuable tool for researchers studying the KCNT1 gene, which encodes a potassium channel linked to epilepsy and neurodevelopmental disorders. This polyclonal antibody, generated in rabbits, exhibits high specificity for human samples and is suitable for use in Western blot applications. By targeting the KCNT1 protein, this antibody enables precise detection and analysis in various cellular contexts, making it an essential reagent for investigations in neuroscience and genetic medicine.KCNT1, also known as Slack channel, is a crucial regulator of neuronal excitability and synaptic transmission, making it a prime candidate for understanding epileptic mechanisms and identifying potential therapeutic targets.

Studies on KCNT1 have provided valuable insights into the pathogenesis of disorders such as epilepsy, developmental delay, and intellectual disability, highlighting its importance in neurological research. Harnessing the functional role of KCNT1 could lead to novel interventions for patients affected by these conditions.

Antibody Name:KCNT1 Antibody (PACO57176)
Antibody SKU:PACO57176
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Potassium channel subfamily T member 1 protein (1026-1230AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageIHC image of PACO57176 diluted at 1:400 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Product ImageImmunofluorescence staining of HepG2 cells with PACO57176 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity).
Synonyms:Potassium channel subfamily T member 1 (KCa4.1), KCNT1, KIAA1422
UniProt Protein Function:KCNT1: Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro). Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 9q34.3Cellular Component: voltage-gated potassium channel complexMolecular Function: calcium-activated potassium channel activity; voltage-gated potassium channel activityDisease: Epilepsy, Nocturnal Frontal Lobe, 5; Epileptic Encephalopathy, Early Infantile, 14
UniProt Protein Details:
NCBI Summary:Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
UniProt Code:Q5JUK3
NCBI GenInfo Identifier:432134244
NCBI Gene ID:57582
NCBI Accession:NP_001258932.1
UniProt Secondary Accession:Q5JUK3,Q9P2C5, B3KXF7, B7ZVY4, B9EGP2, G5E9V0
UniProt Related Accession:Q5JUK3
Molecular Weight:136,987 Da
NCBI Full Name:potassium channel subfamily T member 1 isoform 2
NCBI Synonym Full Names:potassium sodium-activated channel subfamily T member 1
NCBI Official Symbol:KCNT1  
NCBI Official Synonym Symbols:ENFL5; SLACK; EIEE14; KCa4.1; Slo2.2; bA100C15.2  
NCBI Protein Information:potassium channel subfamily T member 1
UniProt Protein Name:Potassium channel subfamily T member 1
UniProt Synonym Protein Names:KCa4.1
Protein Family:Potassium channel subfamily
UniProt Gene Name:KCNT1  
UniProt Entry Name:
Antibodies
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