The KO Validated ATOX1 Rabbit Polyclonal Antibody (CAB19925) is a valuable tool for researchers studying ATOX1, a key protein involved in copper homeostasis and transport. This antibody, produced in rabbits, is highly specific for human samples and has been rigorously validated for use in Western blot applications.ATOX1 is a copper chaperone protein that plays a crucial role in copper metabolism and cellular processes. Dysregulation of copper homeostasis has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes.
Therefore, understanding the function and regulation of ATOX1 is essential for advancing research in these areas.By using the KO Validated ATOX1 Rabbit Polyclonal Antibody, researchers can accurately detect and analyze ATOX1 expression in different cell types and tissues. This antibody is a valuable tool for studies in biochemistry, cell biology, and molecular biology, providing crucial insights into the role of ATOX1 in health and disease.
Product Name:
[KO Validated] ATOX1 Rabbit Polyclonal Antibody
SKU:
CAB19925
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-68 of human ATOX1 (NP_004036.1).
This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.
Purification Method:
Affinity purification
Gene ID:
475
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and ATOX1 knockout (KO) 293T cells, using [KO Validated] ATOX1 Rabbit pAb (CAB19925) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
McGrath et al.
Understanding the Role of MicroRNA-31 in Regulating Cellular Sensitivity to Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma
