Description
Anti-CDA Antibody (CAB19846)[KO Validated]
The KO Validated CDA Rabbit Polyclonal Antibody (CAB19846) is a powerful tool for researchers studying CD300A, an important cell surface molecule involved in immune regulation. This antibody, produced in rabbits, is specifically designed to target the CD300A protein in human samples, making it ideal for Western blot applications. By detecting and analyzing CD300A in various cell types, researchers can gain valuable insights into immune responses, inflammation, and allergic reactions.
CD300A, also known as an immune inhibitory receptor, plays a crucial role in maintaining immune homeostasis and modulating immune function. Its involvement in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions makes it a promising target for therapeutic development. By using the KO Validated CDA Rabbit Polyclonal Antibody, researchers can further explore the role of CD300A in immunology and cancer research, paving the way for new treatment strategies.
| Antibody Name: | Anti-CDA Antibody [KO Validated] |
| Antibody SKU: | CAB19846 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human CDA. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa |
| Immunogen: | Recombinant protein of human CDA. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 978 |
| Uniprot: | P32320 |
| Cellular Location: | |
| Calculated MW: | 16kDa |
| Observed MW: | 14KDa |
![Anti-CDA Antibody [KO Validated] (CAB19846)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/d/610/A19846_1__63543.jpg) | Western blot analysis of extracts from normal (control) and CDA knockout (KO) HeLa cells, using CDA antibody (CAB19846) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| Synonyms: | CDA, CDD |
| Background: | This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. |
| UniProt Protein Function: | CDA: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. Belongs to the cytidine and deoxycytidylate deaminase family. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - pyrimidine; Hydrolase; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 3.5.4.5 Chromosomal Location of Human Ortholog: 1p36.2-p35 Cellular Component: extracellular region; cytosol Molecular Function:protein homodimerization activity; zinc ion binding; nucleoside binding; cytidine deaminase activity Biological Process: cell surface receptor linked signal transduction; pyrimidine base metabolic process; cytosine metabolic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; cytidine deamination; negative regulation of cell growth; pyrimidine salvage; negative regulation of nucleotide metabolic process; protein homotetramerization |
| NCBI Summary: | This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32320 |
| NCBI GenInfo Identifier: | 1705718 |
| NCBI Gene ID: | 978 |
| NCBI Accession: | P32320.2 |
| UniProt Related Accession: | P32320 |
| Molecular Weight: | |
| NCBI Full Name: | Cytidine deaminase |
| NCBI Synonym Full Names: | cytidine deaminase |
| NCBI Official Symbol: | CDAÂ Â |
| NCBI Official Synonym Symbols: | CDDÂ Â |
| NCBI Protein Information: | cytidine deaminase |
| UniProt Protein Name: | Cytidine deaminase |
| UniProt Synonym Protein Names: | Cytidine aminohydrolase |
| Protein Family: | Colicin |
| UniProt Gene Name: | CDAÂ Â |
| UniProt Entry Name: | CDD_HUMAN |
