Description
Anti-FKBP10 Antibody (CAB19870)[KO Validated]
The FKBP10 Polyclonal Antibody (CAB19870) is a reliable tool for researchers studying the FKBP10 protein, which is involved in cellular processes such as protein folding and signaling pathways. This antibody, derived from rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It effectively binds to FKBP10, allowing for precise detection and analysis in various cell types, making it suitable for investigations in fields like immunology and cancer research.
FKBP10 is a critical protein involved in the regulation of collagen biosynthesis and has been implicated in diseases such as osteogenesis imperfecta and Bruck syndrome. Understanding the functions and mechanisms of FKBP10 can provide valuable insights into these disorders and potentially lead to the development of targeted therapies. The FKBP10 Polyclonal Antibody is an indispensable tool for researchers aiming to unravel the complexities of FKBP10 biology in health and disease.
| Antibody Name: | Anti-FKBP10 Antibody [KO Validated] |
| Antibody SKU: | CAB19870 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human FKBP10. |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | 293T |
| Immunogen: | Recombinant protein of human FKBP10. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 60681 |
| Uniprot: | Q96AY3 |
| Cellular Location: | Endoplasmic reticulum lumen |
| Calculated MW: | 38kDa/64kDa |
| Observed MW: | 75KDa |
![Anti-FKBP10 Antibody [KO Validated] (CAB19870)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/r/524/A19870_1__27033.jpg) | Western blot analysis of extracts from normal (control) and FKBP10 knockout (KO) 293T cells, using FKBP10 antibody (CAB19870) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1S. |
| Synonyms: | FKBP10, BRKS1, FKBP65, OI11, OI6, PPIASE, hFKBP65 |
| Background: | The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined. |
| UniProt Protein Function: | FKBP10: PPIases accelerate the folding of proteins during protein synthesis. Defects in FKBP10 are the cause of osteogenesis imperfecta type 6 (OI6). OI6 is a moderate to severe, autosomal recessive form of osteogenesis imperfecta characterized by increased serum alkaline phosphatase levels and bone histology exhibiting a fish scale-like lamellar pattern. Osteogenesis imperfecta defines a group of connective tissue disorders characterized by bone fragility and low bone mass. |
| UniProt Protein Details: | Protein type:Isomerase; EC 5.2.1.8 Chromosomal Location of Human Ortholog: 17q21.2 Cellular Component: endoplasmic reticulum membrane Molecular Function:FK506 binding; peptidyl-prolyl cis-trans isomerase activity Disease: Bruck Syndrome 1; Osteogenesis Imperfecta, Type Xi |
| NCBI Summary: | The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.[provided by RefSeq, Nov 2009] |
| UniProt Code: | Q96AY3 |
| NCBI GenInfo Identifier: | 23396594 |
| NCBI Gene ID: | 60681 |
| NCBI Accession: | Q96AY3.1 |
| UniProt Secondary Accession: | Q96AY3,Q7Z3R4, Q9H3N3, Q9H6J3, Q9H6N5, Q9UF89, |
| UniProt Related Accession: | Q96AY3 |
| Molecular Weight: | 38,950 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase FKBP10 |
| NCBI Synonym Full Names: | FK506 binding protein 10 |
| NCBI Official Symbol: | FKBP10Â Â |
| NCBI Official Synonym Symbols: | OI6; OI11; BRKS1; FKBP65; PPIASE; hFKBP65Â Â |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase FKBP10 |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase FKBP10 |
| UniProt Synonym Protein Names: | 65 kDa FK506-binding protein; 65 kDa FKBP; FKBP-65; FK506-binding protein 10; FKBP-10; Immunophilin FKBP65; Rotamase |
| Protein Family: | Peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | FKBP10Â Â |
| UniProt Entry Name: | FKB10_HUMAN |
