The FTL Polyclonal Antibody (CAB18051) is a reliable tool for researchers studying the FTL protein, a key player in iron metabolism and storage within the body. This antibody, produced in rabbits, has been validated for use in various applications, with a strong reactivity towards human samples. By targeting the FTL protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it a valuable asset for investigations in the fields of biochemistry and molecular biology.The FTL protein, also known as ferritin light chain, is essential for maintaining iron homeostasis within cells, serving as a storage unit for excess iron and participating in iron transport and detoxification processes.
Dysregulation of FTL expression has been implicated in several diseases, including iron-overload disorders and neurodegenerative conditions. By studying the function and regulation of FTL, researchers can gain insights into these pathologies and potentially develop therapeutic strategies to target them.
cytoplasm, cytosol, extracellular exosome, extracellular region
Calculated MW:
20kDa
Observed MW:
20kDa/21kDa
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.
Purification Method:
Affinity purification
Gene ID:
2512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Ferritin Light Chain Rabbit pAb (CAB18051) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
