The SEPHS1 Polyclonal Antibody (CAB19920) is a powerful tool for research involving SEPHS1, a key protein involved in selenoprotein biosynthesis and essential for cellular function. This rabbit polyclonal antibody is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SEPHS1 protein, researchers can effectively study its role in various cellular processes, making this antibody well-suited for investigations in biochemistry and molecular biology.SEPHS1 plays a critical role in the synthesis of selenoproteins, which are important for antioxidant defense and thyroid hormone metabolism.
Dysregulation of SEPHS1 has been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions. By using this antibody to study SEPHS1 expression and activity, researchers can gain valuable insights into the mechanisms underlying these diseases, potentially leading to the development of novel therapeutic strategies targeting selenoprotein biosynthesis.
Product Name:
[KO Validated] SEPHS1 Rabbit Polyclonal Antibody
SKU:
CAB19920
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-392 of human SEPHS1 (NP_036379.2).
This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.
Purification Method:
Affinity purification
Gene ID:
22929
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and SEPHS1 knockout (KO) 293T cells, using [KO Validated] SEPHS1 Rabbit pAb (CAB19920) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
