Description
LAYN Antibody (PACO18143)
The Layn Antibody (PAC018143) is a high-quality polyclonal antibody designed for research involving the Layn protein, a key player in immune regulation and inflammation control. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding to the Layn protein, researchers can detect and analyze Layn expression in various cell types, making it an ideal tool for studies in immunology and cancer research.Layn, also known as an immune regulatory molecule, is essential for maintaining immune homeostasis and modulating inflammatory responses.
Its role in immune function makes it a promising target for investigating diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of Layn is crucial for developing therapeutic strategies that modulate immune responses and inflammation in these disease contexts.Overall, the Layn Antibody (PAC018143) offers researchers a valuable tool for studying Layn protein expression and function, providing insights into its role in immune regulation and potential implications for disease treatment.
| Antibody Name: | LAYN Antibody (PACO18143) |
| Antibody SKU: | PACO18143 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human LAYN |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO18143(LAYN Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
| Background: | Layilin is a recently cloned ˜55-kDa membrane-binding partner for talin (Borowsky and Hynes, 1998 ) that is widely expressed in different cell types and tissue extracts. It is found in peripheral ruffles of spreading cells and is recruited to membrane ruffles in cells induced to migrate in in vitro wounding experiments. Layilin colocalizes with talin in ruffles and binds to talin's ˜50-kDa head domain (amino acid, 280–435). Other parts of talin (the ˜220-kDa tail fragment) can bind β -integrin cytoplasmic tails, vinculin, and F-actin and hence form an integrin-cytoskeleton linkage at sites of cell-substratum contact. Layilin's extracellular domain is homologous with the carbohydrate-recognition domains (CRD) of C-type lectins. |
| Synonyms: | layilin |
| UniProt Protein Function: | LAYN: Receptor for hyaluronate. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q23.1 Cellular Component: ruffle; cell surface; focal adhesion; integral to membrane Molecular Function:hyaluronic acid binding; carbohydrate binding |
| UniProt Code: | Q6UX15 |
| NCBI GenInfo Identifier: | 74738165 |
| NCBI Gene ID: | 143903 |
| NCBI Accession: | Q6UX15.1 |
| UniProt Secondary Accession: | Q6UX15,Q8TAY8, Q96NC5, Q96NF3, A6NJB0, B4DJU0, |
| UniProt Related Accession: | Q6UX15 |
| Molecular Weight: | 382 |
| NCBI Full Name: | Layilin |
| NCBI Synonym Full Names: | layilin |
| NCBI Official Symbol: | LAYNÂ Â |
| NCBI Protein Information: | layilin |
| UniProt Protein Name: | Layilin |
| Protein Family: | Layilin |
| UniProt Gene Name: | LAYNÂ Â |
| UniProt Entry Name: | LAYN_HUMAN |
