The LCN2 Polyclonal Antibody (CAB11130) is specifically designed for research involving Lipocalin-2 (LCN2), a protein involved in various cellular processes, including immune response and iron transport. This antibody, generated in rabbits, exhibits high reactivity towards human samples and is validated for Western blot applications. It binds to the LCN2 protein, enabling accurate detection and analysis in a variety of cell types, making it a valuable tool for studies in immunology, cancer research, and other related fields.LCN2, also known as neutrophil gelatinase-associated lipocalin (NGAL), is a key player in the immune response, acting as both a pro-inflammatory and anti-inflammatory mediator.
Its involvement in iron regulation and antimicrobial defense underscores its importance in the context of various diseases, including cancer, inflammation, and renal disorders. Research on LCN2 provides valuable insights into the mechanisms underlying these conditions and may lead to the development of novel therapeutic strategies targeting this protein.
Product Name:
Lipocalin-2/NGAL Rabbit Polyclonal Antibody
SKU:
CAB11130
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-198 of human Lipocalin-2/NGAL (NP_005555.2).
This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice.
Purification Method:
Affinity purification
Gene ID:
3934
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Lipocalin-2/NGAL antibody (CAB11130) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
