Description
Lipocalin-2/NGAL Polyclonal Antibody (CAB24538)
The Lipocalin-2 (NGAL) Polyclonal Antibody is a valuable tool for research involving Lipocalin-2, a glycoprotein that plays a critical role in various physiological and pathological processes. This antibody, produced in rabbits, is highly specific for human samples and is suitable for use in Western blot and immunohistochemistry applications. By binding to Lipocalin-2, researchers can accurately detect and analyze its expression in different cell types, making it an ideal choice for studies in areas such as kidney disease, inflammation, and cancer research.
Lipocalin-2, also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted protein that is involved in diverse functions such as iron transport, apoptosis, and immune response regulation. Its upregulation has been linked to various diseases including acute kidney injury, bacterial infections, and certain types of cancer. By investigating the role of Lipocalin-2 in these conditions, researchers can gain valuable insights into potential therapeutic targets and biomarkers for diagnosis and treatment.
| Product Name: | Lipocalin-2/NGAL Polyclonal Antibody |
| Product Code: | CAB24538 |
| Reactivity: | Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse uterus, Mouse spleen, Mouse ovary, Rat uterus |
| Cellular Location: | Secreted, Cytoplasmic granule lumen, Cytoplasmic vesicle lumen |
Enables iron ion binding activity. Involved in innate immune response; positive regulation of cold-induced thermogenesis; and siderophore transport. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; response to bacterium; and response to virus. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Human ortholog(s) of this gene implicated in intrahepatic cholangiocarcinoma and urinary tract infection. Orthologous to human LCN2 (lipocalin 2).
| Immunogen: | Recombinant funsion protein containing a sequence corresponding to amino acids 21-200 of mouse Lipocalin-2/NGAL (NP_032517.1). |
| Sequence: | QDSTQ NLIPA PSLLT VPLQP DFRSD QFRGR WYVVG LAGNA VQKKT EGSFT MYSTI YELQE NNSYN VTSIL VRDQD QGCRY WIRTF VPSSR AGQFT LGNMH RYPQV QSYNV QVATT DYNQF AMVFF RKTSE NKQYF KITLY GRTKE LSPEL KERFT RFAKS LGLKD DNIIF SVPTD QCIDN |
| Synonyms: | 24p3, AW212229, NRL, Sip24 |
| Calculated MW: | 23kDa |
| Observed MW: | 23kDa |
