The LTBP1 Polyclonal Antibody (CAB15287) is a valuable tool for research involving LTBP1, an essential component of the extracellular matrix that plays a crucial role in the regulation of transforming growth factor beta (TGF-β) activation and signaling. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for use in various research applications, including Western blotting.LTBP1, or latent TGF-β binding protein 1, is critical for the storage and activation of TGF-β, a key signaling molecule involved in various cellular processes, including cell growth, differentiation, and immune responses.
Dysregulation of LTBP1-TGF-β signaling has been linked to diseases like fibrosis, cancer, and developmental disorders. By studying LTBP1 using this antibody, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets.
Product Name:
LTBP1 Rabbit Polyclonal Antibody
SKU:
CAB15287
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1290-1540 of human LTBP1 (NP_996826.2).
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
4052
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from LO2 cells, using LTBP1 Rabbit pAb (CAB15287) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
