The LTC4S Polyclonal Antibody (CAB15071) is a vital tool for researchers studying leukotriene C4 synthase, an enzyme involved in the production of leukotrienes, lipid mediators that play a key role in inflammation and immune responses. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting LTC4S in human samples, ensuring reliable results in Western blot applications. By targeting the LTC4S protein, this antibody enables precise analysis and investigation of its function in various cell types, making it an essential component of studies in immunology, inflammation, and respiratory disorders.
LTC4S is a crucial enzyme in the biosynthesis of leukotrienes, potent lipid mediators that regulate immune responses, inflammation, and allergic reactions. Dysregulation of leukotriene production has been implicated in various inflammatory conditions, such as asthma, arthritis, and cardiovascular diseases, highlighting the importance of understanding the role of LTC4S in these pathological processes. The LTC4S Polyclonal Antibody provides researchers with a powerful tool to explore the function of this enzyme and its potential as a therapeutic target for intervening in inflammatory diseases.
Product Name:
LTC4S Rabbit Polyclonal Antibody
SKU:
CAB15071
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human LTC4S (NP_665874.1).
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum.
Purification Method:
Affinity purification
Gene ID:
4056
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from A-549 cells, using LTC4S Rabbit pAb (CAB15071) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
