The MAPK6 Polyclonal Antibody (PACO07004) is a valuable tool for researchers studying the MAPK6 protein, a member of the mitogen-activated protein kinase (MAPK) family involved in various cellular processes such as cell proliferation, differentiation, and apoptosis. Raised in rabbits, this antibody is highly specific to human samples and is validated for use in Western blot applications.MAPK6, also known as ERK3, plays a key role in signaling pathways that regulate cell growth and survival, making it a promising target for cancer research and drug development. By binding to the MAPK6 protein, this antibody enables accurate detection and analysis in a variety of cell types, offering insights into the function and regulation of MAPK6 in different biological contexts.
Understanding the role of MAPK6 in cellular signaling pathways is essential for advancing our knowledge of disease mechanisms and identifying potential therapeutic targets. The MAPK6 Polyclonal Antibody is a reliable tool for researchers seeking to unravel the complexities of MAPK6-mediated signaling and its implications in various diseases, including cancer and other related disorders.
Antibody Name:
MAPK6 Antibody
Antibody SKU:
PACO07004
Size:
50 µg
Target Name:
MAPK6
Host Species:
Rabbit
Tested Applications:
WB
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Recombinant Protein
Immunogen Species:
Homo sapiens (Human)
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Conjugate:
Non-conjugated
Storage:
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.
Subcellular Location:
Cytoplasm. Nucleus.
Protein Families:
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, MAP kinase subfamily
Tissue Specificity:
Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
