The MAPT Antibody (PAC021463) is a valuable tool for researchers studying the MAPT protein, also known as tau protein, which plays a key role in neurodegenerative diseases such as Alzheimer's. This polyclonal antibody is meticulously designed for reliable detection and analysis of MAPT in various biological samples. Raised in rabbits, this antibody exhibits high specificity and sensitivity in Western blot applications, providing researchers with accurate and reproducible results. By targeting the MAPT protein, researchers can better understand the mechanisms underlying neurodegenerative diseases and potentially develop novel therapeutic strategies.
The MAPT Antibody is an essential resource for investigations into neurodegenerative disorders and offers a promising avenue for the development of targeted therapies. Its versatility and reliability make it an indispensable tool for researchers seeking to advance our understanding of the role of MAPT in neurological health and disease.
Antibody Name:
Mapt Antibody (PACO21463)
Antibody SKU:
PACO21463
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Peptide sequence around aa. 725-729(T-G-S-I-D) derived from Rat Tau
Form:
Liquid
Storage Buffer:
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099.
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extract from rat brain and mouse brain tissue using TAU Antibody.
Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.
Molecular Function:apolipoprotein binding; DNA binding; enzyme binding; Hsp90 protein binding; identical protein binding; microtubule binding; protein binding; protein complex binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; protein phosphatase 2A binding; receptor agonist activity; SH3 domain binding
Biological Process: adult walking behavior; apoptosis; axon cargo transport; axon extension; axonogenesis; brain development; female pregnancy; induction of apoptosis by oxidative stress; intracellular distribution of mitochondria; memory; microtubule cytoskeleton organization and biogenesis; mitochondrion transport along microtubule; negative regulation of intracellular transport; negative regulation of kinase activity; neurite development; neuron migration; positive regulation of axon extension; positive regulation of microtubule polymerization; positive regulation of superoxide release; regulation of autophagy; regulation of calcium-mediated signaling; regulation of microtubule polymerization or depolymerization; response to nutrient; response to organic substance; synapse organization and biogenesis
NCBI Summary:
a microtubule-associated protein; expression is found specifically in neurons [RGD, Feb 2006]
