The Mast4 Polyclonal Antibody (PAC023721) is a valuable tool for researchers studying Mast4, a protein involved in cell signaling pathways and cellular functions. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By targeting the Mast4 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an excellent choice for studies in cell biology and signal transduction research.
Mast4, also known as microtubule-associated serine/threonine kinase 4, is a key player in regulating cell division, migration, and other essential cellular processes. Its role in cell signaling cascades makes it a promising target for investigating diseases such as cancer, neurodegenerative disorders, and developmental abnormalities. By understanding the function of Mast4, researchers can gain insights into potential therapeutic strategies targeting these conditions.
Synthesized peptide derived from internal of human MAST4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells, COLO cells, HUVEC cells and MCF-7 cells, using MAST4 antibody.
Immunofluorescence analysis of COS-7 cells, using MAST4 antibody.
Immunohistochemistry analysis of paraffin-embedded human testis tissue using MAST4 antibody.
Background:
This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms.
MAST4: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, AGC; AGC group; MAST family
Chromosomal Location of Human Ortholog: 5q12.3
Cellular Component: cytoplasm
Molecular Function:protein serine/threonine kinase activity; magnesium ion binding; ATP binding
Biological Process: protein amino acid phosphorylation
NCBI Summary:
This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
