Description
MED26 Antibody (PACO10443)
The MED26 Antibody (PAC010443) is a vital tool for researchers studying the MED26 protein, a key component of the Mediator complex involved in transcription regulation. This polyclonal antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the MED26 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for studies in molecular biology and gene expression research.
MED26 plays a crucial role in gene transcription regulation, serving as a bridge between transcription factors and the RNA polymerase II complex. Its importance in controlling gene expression makes it a valuable target for research into various diseases, including cancer, developmental disorders, and metabolic conditions. Understanding the function of MED26 is essential for unraveling the mechanisms underlying these diseases and developing targeted therapies to combat them.
| Antibody Name: | MED26 Antibody (PACO10443) |
| Antibody SKU: | PACO10443 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human MED26 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | mediator complex subunit 26;MED26;CRSP7;CRSP70 ;ARC70; |
| UniProt Protein Function: | MED26: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 26 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: nucleoplasm; Srb-mediator complex Molecular Function:protein binding; transcription coactivator activity Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter |
| NCBI Summary: | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95402 |
| NCBI GenInfo Identifier: | 158931130 |
| NCBI Gene ID: | 9441 |
| NCBI Accession: | O95402.2 |
| UniProt Secondary Accession: | O95402,Q0VGB6, A1A4S3, |
| UniProt Related Accession: | O95402 |
| Molecular Weight: | 10,359 Da |
| NCBI Full Name: | Mediator of RNA polymerase II transcription subunit 26 |
| NCBI Synonym Full Names: | mediator complex subunit 26 |
| NCBI Official Symbol: | MED26Â Â |
| NCBI Official Synonym Symbols: | CRSP7; CRSP70Â Â |
| NCBI Protein Information: | mediator of RNA polymerase II transcription subunit 26 |
| UniProt Protein Name: | Mediator of RNA polymerase II transcription subunit 26 |
| UniProt Synonym Protein Names: | Activator-recruited cofactor 70 kDa component; ARC70; Cofactor required for Sp1 transcriptional activation subunit 7; CRSP complex subunit 7; Mediator complex subunit 26; Transcriptional coactivator CRSP70 |
| Protein Family: | Mediator of RNA polymerase II transcription |
| UniProt Gene Name: | MED26Â Â |
| UniProt Entry Name: | MED26_HUMAN |
