The MEF2A Polyclonal Antibody (CAB7911) is a valuable tool for researchers studying the MEF2A protein, a key transcription factor involved in the regulation of gene expression. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By specifically binding to MEF2A, researchers can detect and analyze this important protein in a variety of cell types, making it ideal for investigations in molecular biology and cardiovascular research.MEF2A is essential for the development and function of cardiac and skeletal muscle, playing a crucial role in muscle differentiation and growth.
Dysregulation of MEF2A has been implicated in cardiovascular diseases, muscular disorders, and neurodegenerative conditions. Understanding the mechanisms by which MEF2A regulates gene expression is key to uncovering new therapeutic targets for these diseases. The MEF2A Polyclonal Antibody provides researchers with a powerful tool to study the functions and activity of MEF2A, advancing our knowledge of its role in health and disease.
Product Name:
MEF2A Rabbit Polyclonal Antibody
SKU:
CAB7911
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MEF2A (NP_005578.2).
The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4205
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MEF2A antibody (CAB7911) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
