The Merlin Polyclonal Antibody (CAB2456) is a vital tool for researchers studying the Merlin protein, a tumor suppressor that plays a key role in cell growth and division. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the Merlin protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in cancer biology and cell signaling pathways.
Merlin, also known as neurofibromin 2, is a crucial regulator of cell proliferation and adhesion, and its dysfunction has been linked to various forms of cancer, including mesothelioma and schwannomatosis. Understanding the function and regulation of Merlin is essential for developing targeted therapies for these diseases. The Merlin Polyclonal Antibody provides researchers with a valuable tool to further explore the role of this important protein in cancer development and progression.
Product Name:
NF2 Rabbit Polyclonal Antibody
SKU:
CAB2456
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-595 of human NF2 (NP_000259.1).
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities.
Purification Method:
Affinity purification
Gene ID:
4771
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using NF2 Rabbit pAb (CAB2456) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
