Description
MMP28 Antibody (PACO14714)
The MMP28 Polyclonal Antibody (PACO14714) is an essential tool for researchers studying matrix metalloproteinase 28 (MMP28), a key enzyme involved in extracellular matrix degradation and tissue remodeling. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for various research applications, particularly Western blot analysis. By binding specifically to MMP28, this antibody enables accurate detection and characterization of MMP28 expression in different cell types, offering valuable insights into its functions in physiological and pathological processes.
MMP28, also known as epilysin, is a member of the matrix metalloproteinase family that plays a crucial role in tissue remodeling, wound healing, and cell migration. Its dysregulation has been implicated in various diseases, including cancer, arthritis, and cardiovascular disorders, highlighting the significance of studying MMP28 in different contexts. By investigating the activity and expression of MMP28 using this antibody, researchers can gain a deeper understanding of its role in disease progression and potentially identify new therapeutic targets for intervention.
| Antibody Name: | MMP28 Antibody (PACO14714) |
| Antibody SKU: | PACO14714 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human MMP28 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 12%SDS-PAGE, Lysate: 30 μg, Lane: Mouse heart tissue, Primary antibody: PACO14714(MMP28 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
| Background: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants encoding different isoforms have been described. |
| Synonyms: | matrix metallopeptidase 28 |
| UniProt Protein Function: | MMP28: Can degrade casein. Could play a role in tissues homeostasis and repair. Belongs to the peptidase M10A family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Protease; EC 3.4.24.-; Secreted; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q12 Cellular Component: proteinaceous extracellular matrix; cytoplasm Molecular Function:zinc ion binding; metalloendopeptidase activity; calcium ion binding Biological Process: proteolysis |
| NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q9H239 |
| NCBI GenInfo Identifier: | 37538314 |
| NCBI Gene ID: | 79148 |
| NCBI Accession: | Q9H239.2 |
| UniProt Secondary Accession: | Q9H239,Q96F04, Q96TE2, |
| UniProt Related Accession: | Q9H239 |
| Molecular Weight: | 520 |
| NCBI Full Name: | Matrix metalloproteinase-28 |
| NCBI Synonym Full Names: | matrix metallopeptidase 28 |
| NCBI Official Symbol: | MMP28Â Â |
| NCBI Official Synonym Symbols: | MM28; MMP25; MMP-25; MMP-28; EPILYSINÂ Â |
| NCBI Protein Information: | matrix metalloproteinase-28; matrix metalloprotease MMP25 |
| UniProt Protein Name: | Matrix metalloproteinase-28 |
| UniProt Synonym Protein Names: | Epilysin |
| Protein Family: | Matrix metalloproteinase |
| UniProt Gene Name: | MMP28Â Â |
| UniProt Entry Name: | MMP28_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
