Description
system_update_altDatasheet
| Product Name: | Mouse CD11b monoclonal antibody (FITC) |
| Product Code: | AGIM0499 |
| Size: | 100 µL |
| Reactivity: | Mouse |
| Clone: | M1/70.15 |
| Applications: | Flow Cytometry |
| Conjugate: | FITC |
| Isotype: | IgG2b |
| Host Species: | Rat |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P05555 |
| Background: | CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that noncovalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component. |
| UniProt Protein Function: | Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:8986723, PubMed:9382884, PubMed:9862668). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils (PubMed:8986723). May play a role in mast cell development (PubMed:9862668). |
| UniProt Code: | P05555 |
| NCBI GenInfo Identifier: | 124956 |
| NCBI Gene ID: | 16409 |
| NCBI Accession: | P05555.2 |
| UniProt Secondary Accession: | P05555,Q8CA73, |
| UniProt Related Accession: | P05555 |
| Molecular Weight: | |
| NCBI Full Name: | Integrin alpha-M |
| NCBI Synonym Full Names: | integrin alpha M |
| NCBI Official Symbol: | Itgam  |
| NCBI Official Synonym Symbols: | CR3; CR3A; MAC1; Cd11b; Ly-40; Mac-1; Mac-1a; CD11b/CD18; F730045J24Rik  |
| NCBI Protein Information: | integrin alpha-M |
| UniProt Protein Name: | Integrin alpha-M |
| UniProt Synonym Protein Names: | CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; CD_antigen: CD11b |
| UniProt Gene Name: | Itgam  |
