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PE/Cyanine5 Anti-Mouse CD183/CXCR3 Antibody [CXCR3-173] (AGEL1423)

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SKU AGEL1423
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Armenian Hamster
Isotype IgG2a,k
Clone CXCR3-173
Conjugation PE/Cy5
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Description

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PE/Cyanine5 Anti-Mouse CD183/CXCR3 Antibody [CXCR3-173]

The Mouse CD183 (CXCR3) Monoclonal Antibody PE-Cyanine5 Conjugated (CXCR3-173) is a powerful tool for researchers studying the CXCR3 protein, a chemokine receptor involved in immune responses and inflammation. This antibody, derived from mouse origin, exhibits high specificity and sensitivity for detecting CXCR3 in various cell types. Validated for use in flow cytometry applications, it enables precise analysis and quantification of CXCR3 expression levels.CXCR3, a receptor for the chemokines CXCL9, CXCL10, and CXCL11, plays a crucial role in directing immune cell trafficking and activation during inflammatory responses.

Its dysregulation has been implicated in various diseases, including autoimmune disorders, viral infections, and cancer. Understanding the expression and functions of CXCR3 is essential for unraveling its complex roles in immune modulation and disease pathogenesis.By utilizing the Mouse CD183 (CXCR3) Monoclonal Antibody PE-Cyanine5 Conjugated (CXCR3-173), researchers can delve deeper into the intricate mechanisms involving CXCR3, paving the way for innovative therapeutic approaches targeting immune responses and inflammatory conditions.

Product Title:PE/Cyanine5 Anti-Mouse CD183/CXCR3 Antibody [CXCR3-173]
SKU:AGEL1423
Size:50 Tests, 100 Tests, 200 Tests
Clone No:CXCR3-173
Synonyms:C-X-C chemokine receptor type 3;Cxcr3;CXC-R3;CXCR-3;Interferon-inducible protein 10 receptor;IP-10 receptor;CD183/CXCR3;
Host Species:Armenian Hamster
Reactivity:Mouse
Application:FCM
Isotype:Armenian Hamster IgG
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:O88410
Gene ID:12766
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD183/CXCR3, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca2+ mobilization and chemotaxis in response to C-X-C chemokines, such as IP10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF4 (CXCL4). CXCR3 is expressed primarily on activiated T lymphocytes, NK cells, and some epithelial cells and endothelial cells. It is not expressed on B cells, monocytes or granulocytes.

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