Description
| Product Name: | Mouse CD3/CD28 T Cell Activation Beads |
| SKU: | AKES213 |
| Size: | 1 mL |
| Host Species: | Hamster |
| Reactivity: | Mouse |
| Feature: | Activation and expansion of sorted T cells or T cells from mouse spleen |
| Form: | Liquid |
| Isolation Technology: | Magnetic Beads |
| Sample Type: | Spleen, Lymph nodes, Whole blood, Pre-isolated T-cells |
| Clonality: | Monoclonal |
| Cell Type: | T cells |
| Formulation: | Consists of 1×108 beads dissolved in phosphate buffered saline (PBS) |
| Usage: | Add 10 µL of beads per 1×106 T cells |
| Storage: | This product can be stored at 2-8°C for 12 months, do not freeze. |
| Description: | Two types of signals are required to induce T cell activation and proliferation: one is a specific antigen-stimulating signal generated by the binding of TCR/CD3 complex to the specific MHC II antigen-peptide complex on the surface of antigen-presenting cells (APCs); the other is a non-specific co-stimulatory signal generated by the interaction of co-stimulatory molecules on the surface of APCs with the corresponding receptors on the T cells, of which CD28 is one of the co-stimulatory molecule. The Mouse CD3/CD28 T Cell Activation Beads is used for activation and expansion of sorted mouse T cells or T cells from mouse spleen. |
| Intend Use: | Mouse CD3/CD28 T Cell Activation Beads are made by coupling anti-CD3 and anti-CD28 antibodies to magnetic beads, which can provide the primary TCR signal and co-stimulatory signals required for T-cell activation and expansion, thus inducing T-cell activation and proliferation in vitro. For subsequent relevant experimental studies, this beads can be removed from cultured cells by using a magnetic rack. |
