The Mouse CD335 Monoclonal Antibody (FITC Conjugated) 29A1-4 is a highly specific antibody designed for research involving CD335, a cell surface molecule known as NKp46 which plays a critical role in natural killer (NK) cell function. This monoclonal antibody, conjugated with FITC for fluorescent detection, is ideal for flow cytometry and immunofluorescence analyses. It specifically targets CD335, enabling precise detection and quantification of NKp46 expression in various cell populations.NKp46, a key activating receptor on NK cells, is essential for the recognition and elimination of infected or transformed cells, contributing to immune surveillance and antitumor immunity.
Understanding the expression and function of CD335 is fundamental in elucidating NK cell biology, immune responses, and the development of immunotherapies targeting NK cells. The unique specificity and reliability of the 29A1-4 antibody make it a valuable tool for researchers studying NKp46-mediated immune responses, immunotherapy, and infectious diseases.
Product Title:
FITC Anti-Mouse CD335 Antibody [29A1.4]
SKU:
AGEL1933
Size:
50 Tests, 100 Tests, 200 Tests
Clone No:
29A1.4
Synonyms:
Ly94;mAR-1;NK-p46;mNKp46;Lymphocyte antigen 94;
Host Species:
Rat
Reactivity:
Mouse
Application:
FCM
Isotype:
Rat IgG2a, κ
Isotype Control:
FITC Rat IgG2a, κ Isotype Control[2A3]
Form:
Liquid
Conjugation:
FITC
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
Q8C567
Gene ID:
17086
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD335, also known as NKp46, is a single-pass type I membrane protein of 46 kD. It belongs to the natural cytotoxicity receptor (NCR) family and contains two Ig-like (immunoglobulin-like) domains. It's expression is restricted to NK cells and a subset of NKT cells; it's not expressed in CD1d-restricted NKT cells. CD335 is a receptor for viral hemagglutinins and heparan sulfate proteoglycans and is involved in NK cell activation.
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