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PerCP/Cyanine5.5 Anti-Mouse CD54 Antibody [YN1/1.7.4] (AGEL0717)

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SKU AGEL0717
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone YN1/1.7.4
Conjugation PerCP/Cy5.5
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Description

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PerCP/Cyanine5.5 Anti-Mouse CD54 Antibody [YN1/1.7.4]

The Mouse CD54 Monoclonal Antibody (PerCP-Cyanine5.5 Conjugated, YN1/1.7.4) is a specialized research tool designed for studying CD54, a key cell surface molecule involved in immune responses. This antibody, derived from mouse hybridomas, is specifically engineered for use in flow cytometry and related applications. It targets the CD54 protein, facilitating its detection and analysis in various biological samples, thereby enabling researchers to delve deeper into immune system processes and inflammatory reactions.CD54, also known as intercellular adhesion molecule-1 (ICAM-1), plays a crucial role in immune cell interactions by mediating adhesion and signaling events.

Its involvement in immune cell activation, migration, and inflammation makes it a significant target for investigation in fields such as immunology, inflammation, and infectious diseases. By understanding the functions and regulation of CD54, researchers can gain insights into immune responses and potentially develop novel therapeutic strategies for conditions characterized by dysregulated immune activation.

Product Title:PerCP/Cyanine5.5 Anti-Mouse CD54 Antibody [YN1/1.7.4]
SKU:AGEL0717
Size:25µg, 100µg
Clone No:YN1/1.7.4
Synonyms:Intercellular adhesion molecule 1;Icam1;MALA-2;MyD10;CD54;Icam-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:PerCP/Cyanine5.5 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P13597
Gene ID:15894
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

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