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Key Features

PerCP/Cyanine5.5 Anti-Human/Mouse CD44 Antibody [IM7] (AGEL1287)

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SKU AGEL1287
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FC
Reactivity Human
Reactivity Mouse
Host Species Rat
Isotype IgG2a,k
Clone IM7
Conjugation PerCP/Cy5.5
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Description

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PerCP/Cyanine5.5 Anti-Human/Mouse CD44 Antibody [IM7]

The Mouse/Human CD44 Monoclonal Antibody (PERCP-Cyanine5.5 Conjugated, IM7) is a versatile tool for research applications involving CD44, a cell surface glycoprotein involved in cell adhesion, migration, and signaling. This antibody, conjugated with PERCP-Cyanine5.5, provides a fluorescent signal for flow cytometry, allowing for the analysis and identification of CD44-expressing cells in both mouse and human samples. The IM7 monoclonal antibody specifically targets CD44, enabling precise detection and characterization of this protein across different cell types.CD44 is a multifunctional molecule with diverse roles in processes such as lymphocyte activation, tumor metastasis, and inflammation.

Its aberrant expression has been implicated in various pathological conditions, including cancer and inflammatory diseases. By targeting CD44, researchers can gain insights into its biological functions and molecular interactions, paving the way for advancements in fields such as immunology, oncology, and regenerative medicine.With its high specificity and compatibility with flow cytometry techniques, the Mouse/Human CD44 Monoclonal Antibody (PERCP-Cyanine5.5 Conjugated, IM7) is a valuable tool for investigating CD44 biology, unraveling its implications in health and disease, and exploring potential therapeutic interventions targeting this pivotal molecule.

Product Title:PerCP/Cyanine5.5 Anti-Human/Mouse CD44 Antibody [IM7]
SKU:AGEL1287
Size:25µg, 100µg
Clone No:IM7
Synonyms:CD44 antigen;CD44;CDw44;Epican;Phagocytic glycoprotein 1;PGP-1;Phagocytic glycoprotein I;PGP-I;CD44;LHR; MDU2; MDU3; MIC4;
Host Species:Rat
Reactivity:Human;Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:PerCP/Cyanine5.5 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P15379 P16070
Gene ID:12505,960
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

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