The MRPL16 Polyclonal Antibody (PAC023354) is a valuable tool for researchers studying MRPL16, a protein involved in mitochondrial ribosome assembly. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for experiments such as Western blotting. By binding to MRPL16, the antibody enables precise detection and analysis of the protein in diverse cell types, facilitating investigations in areas like biochemistry and mitochondrial biology.
MRPL16, a key player in ribosome biogenesis, is essential for maintaining mitochondrial function and cell viability. Dysregulation of MRPL16 has been linked to mitochondrial disorders, cancer, and other diseases, making it a promising target for therapeutic interventions. Studying the function of MRPL16 using this antibody may provide valuable insights into the molecular mechanisms underlying these conditions, ultimately paving the way for the development of novel treatment strategies.
Synthesized peptide derived from internal of human MRPL16.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from 293 cells, using MRPL16 antibody.
Immunohistochemistry analysis of paraffin-embedded human heart tissue using MRPL16 antibody.
Background:
Component of the large subunit of mitochondrial ribosome.
Synonyms:
39S ribosomal protein L16; mitochondrial; L16mt; mitochondrial ribosomal protein L16; MRP-L16
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
