The MRPL33 Polyclonal Antibody (PACO05777) is ideal for researchers studying the MRPL33 protein, a key component of mitochondrial ribosomes involved in protein synthesis. This antibody was raised in rabbits and has been validated for use in Western blot applications with human samples.MRPL33 is essential for mitochondrial function and plays a crucial role in maintaining cellular energy production. Dysregulation of MRPL33 has been associated with various diseases, including mitochondrial disorders and cancer.
By using the MRPL33 Polyclonal Antibody, researchers can detect and analyze the MRPL33 protein in different cell types, aiding in the study of mitochondrial dysfunction and its implications in disease pathology.Understanding the function and regulation of MRPL33 is vital for developing targeted therapies for diseases linked to mitochondrial dysfunction. The MRPL33 Polyclonal Antibody is a valuable tool for researchers looking to further investigate the role of this protein in health and disease.
Antibody Name:
MRPL33 Antibody (PACO05777)
Antibody SKU:
PACO05777
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:10000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the N-terminal region of human MRP-L33.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MRPL33; C2orf1; 39S ribosomal protein L33; mitochondrial; L33mt; MRP-L33
UniProt Protein Function:
MRPL33: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 2p21Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunitMolecular Function: structural constituent of ribosome
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
