The MSI1 Polyclonal Antibody (PAC020824) is a powerful tool for researchers studying MSI1, a key regulator of stem cell function and tumorigenesis. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for various applications including Western blot analysis. By binding to the MSI1 protein, this antibody facilitates the detection and study of MSI1 expression in different cell types.MSI1 is known for its role in maintaining the self-renewal and differentiation of stem cells, as well as promoting tumorigenesis in various cancer types.
Researchers interested in investigating the mechanisms underlying these processes, as well as exploring potential therapeutic interventions, will find the MSI1 Polyclonal Antibody invaluable for their studies. Its application in immunology and cancer research makes it a versatile tool for furthering our understanding of MSI1-related pathways and diseases.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20824(MSI1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 12%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20824(MSI1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 5 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20824(MSI1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13.
Synonyms:
musashi RNA-binding protein 1
UniProt Protein Function:
Musashi-1: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. Belongs to the Musashi family.
UniProt Protein Details:
Protein type:RNA-binding
Chromosomal Location of Human Ortholog: 12q24
Molecular Function:RNA binding
Biological Process: nervous system development
NCBI Summary:
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]
