The MUC7 Antibody (PAC020977) is a polyclonal antibody specifically designed for research involving MUC7, a mucin protein found in saliva and oral mucosa. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blotting and immunohistochemistry. By binding to the MUC7 protein, this antibody enables researchers to detect and analyze MUC7 expression in different cell types, making it ideal for studies in oral health, mucosal immunology, and infectious diseases.
MUC7 is a crucial component of the oral defense system, providing protection against pathogens and maintaining oral health. Its role in mucosal immunity and disease prevention makes it a valuable target for research into conditions like periodontal disease, oral infections, and oral cancer. Understanding the function of MUC7 is essential for developing strategies to promote oral health and prevent oral diseases.
Antibody Name:
MUC7 Antibody (PACO20977)
Antibody SKU:
PACO20977
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:20-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MUC7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20977(MUC7 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20977(MUC7 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acid, . This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.
Synonyms:
mucin 7, secreted
UniProt Protein Function:
Function: May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.2 PublicationsManual assertion based on experiment in:Ref.5
NCBI Summary:
This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.[provided by RefSeq, Feb 2009]
