The NAALADL2 Monoclonal Antibody (PAC036230) is a powerful tool for research involving NAALADL2, a key protein involved in neurotransmission and synaptic plasticity. This antibody, produced using hybridoma technology, is highly specific to human samples and has been validated for use in various research applications, including immunofluorescence and flow cytometry.NAALADL2, also known as N-acetylated-alpha-linked acidic dipeptidase-like 2, is a promising target for studying neurological disorders and synaptic function. Its role in modulating glutamatergic signaling in the brain makes it a potential therapeutic target for conditions like Alzheimer's disease, schizophrenia, and autism spectrum disorders.
By understanding the function and regulation of NAALADL2, researchers can uncover new insights into the pathophysiology of these complex neurological conditions.This monoclonal antibody specifically binds to NAALADL2, allowing for precise detection and analysis in neuronal cell types. Its high specificity and sensitivity make it an ideal tool for investigating the role of NAALADL2 in synaptic transmission and plasticity, offering valuable insights into the mechanisms underlying neurological diseases.
Western Blot. Positive WB detected in: Mouse lung tissue, Mouse kidney tissue. All lanes: NAALADL2 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 89, 37 kDa. Observed band size: 89 kDa.
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO36230 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO36230 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May be catalytically inactive.
Synonyms:
Inactive N-acetylated-alpha-linked acid, c dipeptidase-like protein 2 (NAALADase L2), NAALADL2
UniProt Protein Function:
Function: May be catalytically inactive.Subcellular location: Membrane; Single-pass type II membrane protein Potential. Tissue specificity: Expressed at higher level in kidney and placenta. In embryo, it is mainly confined to duodenal and stomach endoderm, mesonephros, metanephros and pancreas.Miscellaneous: The gene maps to 3q26.31, a region associated with Cornelia de Lange syndrome. However, Ref.1 failed to identify specific mutations in a panel of DNA samples from patients with Cornelia de Lange syndrome.Sequence similarities: Belongs to the peptidase M28 family. M28B subfamily.Caution: Although related to the peptidase M28 family, it lacks the conserved zinc-binding and active sites and therefore has probably lost hydrolase activity.Sequence caution: The sequence CAE54974.2 differs from that shown. Reason: Contaminating sequence at the C-terminus.The sequence CAH56310.1 differs from that shown. Reason: Frameshift at positions 509 and 518.
