Description
NCOR2 Transcription Factor Activity Assay
The NCOR2 Transcription Factor Activity Assay Kit is specifically designed to accurately measure the transcription factor activity of NCOR2 in cell lysates. This kit provides high sensitivity and specificity, ensuring precise and reproducible results for research purposes.NCOR2, or Nuclear Receptor Corepressor 2, is a key protein involved in gene regulation and plays a crucial role in various cellular processes.
Dysregulation of NCOR2 has been linked to diseases such as cancer, metabolic disorders, and neurodegenerative diseases, making it a valuable target for therapeutic interventions.With the NCOR2 Transcription Factor Activity Assay Kit, researchers can gain insights into the functional activity of NCOR2 and its role in disease pathogenesis, ultimately leading to the development of novel treatment strategies.
| Product Name: | NCOR2 Transcription Factor Activity Assay |
| Product Code: | TFAB00137 |
| Target: | NCOR2 |
| Synonyms: | CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, SMRT, T3 receptor-associating factor, TRAC, Thyroid-, retinoic-acid-receptor-associated corepressor |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie NCOR2 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. |
| NCBI Summary: | This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011] |
| UniProt Code: | Q9Y618 |
| NCBI GenInfo Identifier: | 226713806 |
| NCBI Gene ID: | 9612 |
| NCBI Accession: | Q9Y618.2 |
| UniProt Secondary Accession: | Q9Y618,O00613, O15416, O15421, Q13354, Q56D06, Q59GM0 Q9Y5U0, |
| UniProt Related Accession: | Q9Y618 |
| Molecular Weight: | |
| NCBI Full Name: | Nuclear receptor corepressor 2 |
| NCBI Synonym Full Names: | nuclear receptor corepressor 2 |
| NCBI Official Symbol: | NCOR2Â Â |
| NCBI Official Synonym Symbols: | SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau  |
| NCBI Protein Information: | nuclear receptor corepressor 2 |
| UniProt Protein Name: | Nuclear receptor corepressor 2 |
| UniProt Synonym Protein Names: | CTG repeat protein 26; SMAP270; Silencing mediator of retinoic acid and thyroid hormone receptor; SMRT; T3 receptor-associating factor; TRAC; Thyroid-, retinoic-acid-receptor-associated corepressor |
| Protein Family: | Nuclear receptor corepressor |
| UniProt Gene Name: | NCOR2Â Â |
| UniProt Entry Name: | NCOR2_HUMAN |
