Description
NEGR1 Antibody (PACO28542)
The NEGR1 Polyclonal Antibody (PACO28542) is a valuable tool for researchers studying NEGR1, a cell adhesion molecule involved in neuronal development and synaptic plasticity. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the NEGR1 protein, this antibody enables the detection and analysis of NEGR1 expression in various cell types, making it an ideal choice for investigations in neuroscience and neurodevelopmental disorders.NEGR1, also known as neuronal growth regulator 1, plays a crucial role in neuronal connectivity and synaptic function, making it a key player in brain development and neural circuitry formation.
Dysregulation of NEGR1 has been implicated in neurological disorders such as autism and schizophrenia, highlighting its importance in understanding neurodevelopmental processes and potential therapeutic interventions. By studying the function of NEGR1, researchers can gain insight into the mechanisms underlying these disorders and potentially identify new targets for drug development.
| Antibody Name: | NEGR1 Antibody (PACO28542) |
| Antibody SKU: | PACO28542 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Neuronal growth regulator 1 protein (1-196AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: NEGR1 antibody at 4µg/ml + U87 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 39, 25 kDa Observed band size: 25 kDa . |
 | Immunohistochemistry analysis of human testis tissue using PACO28542 at dilution of 1:100. |
 | Immunohistochemistry analysis of human skeletal muscle tissue using PACO28542 at dilution of 1:100. |
| Background: | May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity). |
| Synonyms: | Neuronal growth regulator 1 (IgLON family member 4), NEGR1, IGLON4 |
| UniProt Protein Function: | NEGR1: May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain. Belongs to the immunoglobulin superfamily. IgLON family.Protein type: Membrane protein, GPI anchorChromosomal Location of Human Ortholog: 1p31.1Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q7Z3B1 |
| NCBI GenInfo Identifier: | 88984537 |
| NCBI Gene ID: | 257194 |
| NCBI Accession: | Q7Z3B1.3 |
| UniProt Secondary Accession: | Q7Z3B1,Q5VT21, Q6UY06, Q8N440, Q8NAQ3 |
| UniProt Related Accession: | Q7Z3B1 |
| Molecular Weight: | 24,733 Da |
| NCBI Full Name: | Neuronal growth regulator 1 |
| NCBI Synonym Full Names: | neuronal growth regulator 1 |
| NCBI Official Symbol: | NEGR1Â Â |
| NCBI Official Synonym Symbols: | Ntra; KILON; IGLON4; DMML2433Â Â |
| NCBI Protein Information: | neuronal growth regulator 1 |
| UniProt Protein Name: | Neuronal growth regulator 1 |
| UniProt Synonym Protein Names: | IgLON family member 4 |
| Protein Family: | Neuronal growth regulator |
| UniProt Gene Name: | NEGR1Â Â |
| UniProt Entry Name: | NEGR1_HUMAN |
| Antibodies |
| NEGR1 Antibody (PACO01152) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
