The NRXN3 Antibody (CAB10269) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By targeting the Neurexin 3 protein, researchers can effectively detect and analyze its expression in various cell types, making it a versatile tool for neuroscience and neurobiology studies.Neurexin 3 plays a critical role in mediating synaptic transmission and connectivity in the brain, making it a key player in neurological disorders and conditions such as autism spectrum disorders and schizophrenia.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
NRXN3 Antibody
SKU:
CAB10269
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
C14orf60, NRXN3
Positive Sample:
SGC-7901, Mouse liver, Rat liver
Cellular Localization:
Membrane, Single-Pass Type I Membrane Protein.
Calculated MW:
43kDa/47kDa/50kDa/69kDa/117kDa/153kDa/180kDa
Observed MW:
140kDa
This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder.
Purification Method
Affinity purification
Gene ID
9369
RRID
AB_2757797
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using NRXN3 Rabbit pAb (CAB10269) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
