The NMBR Polyclonal Antibody (PACO07016) is a valuable tool for researchers studying the neurotensin receptor NMBR, a G protein-coupled receptor involved in the regulation of various physiological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the NMBR protein, researchers can accurately detect and analyze its expression in different cell types, making it an ideal choice for studies in neuroscience and drug development.
NMBR is known for its role in modulating neurotransmission, pain perception, and gastrointestinal functions, among other biological activities. Its involvement in various physiological pathways makes it a promising target for therapeutic interventions in conditions such as chronic pain, neurological disorders, and gastrointestinal diseases. By gaining a deeper understanding of NMBR activity, researchers can potentially develop novel treatment strategies that target this receptor for improved patient outcomes.
Antibody Name:
NMBR Antibody (PACO07016)
Antibody SKU:
PACO07016
Size:
50ug
Host Species:
Rabbit
Tested Applications:
WB, IHC
Recommended Dilutions:
WB:1:1000-1:2000, IHC:1:200-1:500
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic Peptide
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:
Affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of 1) Human Brain Tissue, 2) Rat Brain Tissue using NMBR Polyclonal Antibody.
Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using NMBR Polyclonal Antibody.
Synonyms:
Neuromedin-B receptor
UniProt Protein Function:
NMBR: Receptor for neuromedin-B. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integralChromosomal Location of Human Ortholog: 6q24.1Cellular Component: cytoplasm; integral to plasma membrane; plasma membraneBiological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
UniProt Protein Details:
NCBI Summary:
This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
