The NMNAT1 Polyclonal Antibody (CAB4937) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the NMNAT1 protein, researchers can easily detect and analyze its expression in various cell types, making it an ideal choice for studies in metabolism, aging, and neurodegenerative diseases.NMNAT1 plays a crucial role in maintaining cellular NAD levels, which are essential for numerous biological processes including energy metabolism, DNA repair, and cell signaling.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
NMNAT1 Polyclonal Antibody
SKU:
CAB4937
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
LCA9, NMNAT, PNAT1, SHILCA, NMNAT1
Positive Sample:
293T
Cellular Localization:
Nucleus.
Calculated MW:
32kDa
Observed MW:
29kDa
This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15.
Purification Method
Affinity purification
Gene ID
64802
RRID
AB_2765941
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using NMNAT1 Rabbit pAb (CAB4937) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s.
